American Psychiatric Association, D. and A.P. Association, Diagnostic and statistical manual of mental disorders: DSM-5. Vol. 5. 2013: American psychiatric association Washington, DC.
Morris-Rosendahl DJ, Crocq MA. Neurodevelopmental disorders-the history and future of a diagnostic concept. Dialogues Clin Neurosci. 2020;22(1):65–72.
Google Scholar
Francés L, et al. Current state of knowledge on the prevalence of neurodevelopmental disorders in childhood according to the DSM-5: a systematic review in accordance with the PRISMA criteria. Child Adolesc Psychiatry Ment Health. 2022;16(1):27.
Google Scholar
De Felice A, et al. Multifactorial origin of neurodevelopmental disorders: approaches to understanding complex etiologies. Toxics. 2015;3(1):89–129.
Google Scholar
Lavezzi AM, Colizzi M, Lein PJ. EDITORIAL” Advances in understanding the pathogenetic mechanisms of neurodevelopmental disorders and neurodegenerative disease-The environment as a putative risk factor”. Front Neurol. 2023;14:1259772.
Google Scholar
Parenti I, et al. Neurodevelopmental disorders: from genetics to functional pathways. Trends Neurosci. 2020;43(8):608–21.
Google Scholar
Wang F, et al. Personalized nutrition: A review of genotype-based nutritional supplementation. Front Nutr. 2022;9: 992986.
Google Scholar
Toledo ARL, et al. Gut–brain axis as a pathological and therapeutic target for neurodegenerative disorders. Int J Mol Sci. 2022;23(3):1184.
Google Scholar
Carabotti M, et al. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology. 2015;28(2):203.
Lu S, et al. The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review. Biomed Pharmacother. 2024;178: 117207.
Google Scholar
Chen P, et al. Brain-gut axis and psychiatric disorders: A perspective from bibliometric and visual analysis. Front Immunol. 2022;13:1047007.
Google Scholar
Wang Q, Yang Q, Liu X. The microbiota–gut–brain axis and neurodevelopmental disorders. Protein & Cell. 2023;14(10):762–75.
Google Scholar
Leader G, et al. Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review. Nutr. 2022;14:1471.
Leader G, et al. Attention deficit hyperactivity disorder (ADHD) symptoms, comorbid psychopathology, behaviour problems and gastrointestinal symptoms in children and adolescents with autism spectrum disorder. Irish J Psycholo Med. 2022;39(3):240–50.
Google Scholar
Merlo G, Bachtel G, Sugden S. Gut microbiota, nutrition, and mental health. Front Nutr. 2024;11:1337889.
Google Scholar
Zheng Y, et al. The Effects of Food Nutrients and Bioactive Compounds on the Gut Microbiota: A Comprehensive Review. Foods. 2024;13(9):1345.
Google Scholar
Arnold LE, et al. Probiotics for gastrointestinal symptoms and quality of life in autism: a placebo-controlled pilot trial. J Child Adolesc Psychopharmacol. 2019;29(9):659–69.
Google Scholar
Verduci E, et al. Nutrition, Microbiota and Role of Gut-Brain Axis in Subjects with Phenylketonuria (PKU): A Review. Nutrients. 2020;12:3319.
Google Scholar
David LA, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559–63.
Google Scholar
Hildebrandt MA, et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterol. 2009;137(5):1716-1724. e2.
Google Scholar
Turnbaugh PJ, et al. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe. 2008;3(4):213–23.
Google Scholar
Cani PD, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–72.
Google Scholar
Santocchi E, et al. Effects of probiotic supplementation on gastrointestinal, sensory and core symptoms in autism spectrum disorders: a randomized controlled trial. Front Psych. 2020;11: 550593.
Google Scholar
Mari-Bauset S, et al. Evidence of the gluten-free and casein-free diet in autism spectrum disorders: a systematic review. J Child Neurol. 2014;29(12):1718–27.
Google Scholar
Castro K, et al. Effect of a ketogenic diet on autism spectrum disorder: A systematic review. Research in Autism Spectrum Disorders. 2015;20:31–8.
Google Scholar
Heilskov Rytter MJ, et al. Diet in the treatment of ADHD in children—A systematic review of the literature. Nord J Psychiatry. 2015;69(1):1–18.
Google Scholar
Gan J, et al. The effect of vitamin D supplementation on attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of randomized controlled trials. J Child Adolesc Psychopharmacol. 2019;29(9):670–87.
Google Scholar
Curtis LT, Patel K. Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder (ADHD): a review. The Journal of Alternative and Complementary Medicine. 2008;14(1):79–85.
Google Scholar
Higgins J, et al., Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Handbook for Systematic Reviews of Interventions, 2019.
Page MJ, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. J Clin Epidemiol. 2021;134:178–89.
Google Scholar
Higgins JP, Green S. Green, Cochrane handbook for systematic reviews of interventions. 2008.
Sterne JA, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355: i4919.
Google Scholar
Campbell M, et al. Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ. 2020;368: l6890.
Google Scholar
Wang Y, et al. Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder. Pharmacol Res. 2020;157: 104784.
Google Scholar
Wang LJ, et al. Effect of Bifidobacterium bifidum on Clinical Characteristics and Gut Microbiota in Attention-Deficit/Hyperactivity Disorder. J Pers Med. 2022;12(2):227.
Google Scholar
Wang LJ, et al. Add-On Bifidobacterium Bifidum Supplement in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2024;16(14):2260.
Google Scholar
Trezzi S, et al. Behavioural, cognitive, and neurophysiological effects of a synbiotic supplementation enriched with pigmented corn extract or cornstarch in drug-naïve children with attention-deficit hyperactivity disorder: A randomised, double-blind, comparison-controlled clinical trial. Clin Nutr ESPEN. 2025;65:408–17.
Google Scholar
Stevens AJ, et al. Human gut microbiome changes during a 10 week Randomised Control Trial for micronutrient supplementation in children with attention deficit hyperactivity disorder. Sci Rep. 2019;9(1):10128.
Google Scholar
Sherman HT, et al. Carbon monoxide (CO) correlates with symptom severity, autoimmunity, and responses to probiotics treatment in a cohort of children with autism spectrum disorder (ASD): a post-hoc analysis of a randomized controlled trial. BMC Psychiatry. 2022;22(1):536.
Google Scholar
Shaaban SY, et al. The role of probiotics in children with autism spectrum disorder: A prospective, open-label study. Nutr Neurosci. 2018;21(9):676–81.
Google Scholar
Sanctuary MR, et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLoS ONE. 2019;14(1):e0210064.
Google Scholar
Raghavan K, et al. Benefits of Gut Microbiota Reconstitution by Beta 1,3–1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases. J Alzheimers Dis. 2023;94(s1):S241-s252.
Google Scholar
Phan J, et al. Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder. mSystems. 2024;9(5):0050324.
Google Scholar
Pärtty A, et al. A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatr Res. 2015;77(6):823–8.
Google Scholar
Palmer JK, et al. A Double-Blind Randomised Controlled Trial of Prebiotic Supplementation in Children with Autism: Effects on Parental Quality of Life, Child Behaviour, Gastrointestinal Symptoms, and the Microbiome. J Autism Dev Disord, 2024.
Mitchell LK. et al., Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy. Journal of Autism and Developmental Disorders. 2024.
Liu J, et al. Effect of vitamin A supplementation on gut microbiota in children with autism spectrum disorders – a pilot study. BMC Microbiol. 2017;17(1):204.
Google Scholar
Lawrence K, et al. Trialling a microbiome-targeted dietary intervention in children with ADHD-the rationale and a non-randomised feasibility study. Pilot Feasibility Stud. 2022;8(1):108.
Google Scholar
Hrnciarova J, et al. Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study. Nutri. 2024;16(13):1988.
Google Scholar
Capra SM, Hannan-Jones M. A controlled dietary trial for improving bowel function in a group of training centre residents with severe or profound intellectual disability1. Australia and New Zealand J Develop Disabil. 1992;18(2):111–21.
Google Scholar
Billeci L, et al. A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism. Autism. 2023;27(1):117–32.
Google Scholar
Adams JB, Holloway C. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. J Altern Complement Med. 2004;10(6):1033–9.
Google Scholar
Abele S, et al. Specific Carbohydrate Diet (SCD/GAPS) and Dietary Supplements for Children with Autistic Spectrum Disorder. Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 2021;75:417–425.
Ng QX, et al. A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders. Medicina (Kaunas). 2019;55(5):129.
Google Scholar
Sivamaruthi B, et al. The role of microbiome, dietary supplements, and probiotics in autism spectrum disorder. 2020.
Patel M, et al. A Systematic Review of Mixed Studies Exploring the Effects of Probiotics on Gut-Microbiome to Modulate Therapy in Children With Autism Spectrum Disorder. Cureus. 2022;14:e32313.
Google Scholar
Ansari F, et al. The role of probiotics and prebiotics in modulating of the gut-brain axis. Front Nutr. 2023;10:1173660.
Google Scholar
Bundgaard-Nielsen C, et al. Children and adolescents with attention deficit hyperactivity disorder and autism spectrum disorder share distinct microbiota compositions. Gut Microbes. 2023;15(1):2211923.
Google Scholar
Pham H, et al. The effect of vitamin D supplementation on the gut microbiome in older Australians – Results from analyses of the D-Health Trial. Gut Microbes. 2023;15(1):2221429.
Google Scholar
Bisle E, Varadarajan S, Kolassa I-T. Vitamin-mediated interaction between the gut microbiome and mitochondria in depression: A systematic review-based integrated perspective. Brain, Behavior, & Immunity – Health. 2024;38: 100790.
Google Scholar
El-Sayed R, et al., Role of vitamins and nutrients in the management of attention-deficit hyperactivity disorder (ADHD): a narrative review. 2024.
Kerna N, et al. The Gut-Brain Axis in Neurodevelopmental Disorders: Mechanistic Insights, Clinical Implications, and Public Health Strategies. European Journal of Theoretical and Applied Sciences. 2024;2:580–96.
Google Scholar
Menezes AA, Shah ZA. A Review of the Consequences of Gut Microbiota in Neurodegenerative Disorders and Aging. Brain Sci. 2024;14(12):1224.
Google Scholar
Singh R, et al. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat Commun. 2019;10(1):89.
Google Scholar
Lobionda S, et al. The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors. Microorganisms. 2019;7(8).
Restrepo B, et al. Developmental–behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms. Autism Res. 2020;13(10):1778–89.
Google Scholar
Fulceri F, et al. Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder. Dig Liver Dis. 2016;48(3):248–54.
Google Scholar
Marano G, et al. The Microbiota-Gut-Brain Axis: Psychoneuroimmunological Insights. Nutr. 2023;15(6):1496.
Google Scholar
Mulle JG, Sharp WG, Cubells JF. The gut microbiome: a new frontier in autism research. Curr Psychiatry Rep. 2013;15(2):337.
Google Scholar
Sittipo P, et al. The function of gut microbiota in immune-related neurological disorders: a review. J Neuroinflammation. 2022;19(1):154.
Google Scholar
Jurek L, et al. Is there a dysbiosis in individuals with a neurodevelopmental disorder compared to controls over the course of development? A systematic review. Eur Child Adolesc Psychiatry. 2021;30(11):1671–94.
Google Scholar
Bundgaard-Nielsen C, et al. Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review. Gut Microbes. 2020;11(5):1172–87.
Google Scholar
Checa-Ros A, et al. Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications. Nutr. 2021;13(1):249.
Bradley-Ridout G, et al. The gut microbiome in children with mood, anxiety, and neurodevelopmental disorders: An umbrella review. Gut Microbiome. 2023;4: e18.
Google Scholar
Wang Q, Yang Q, Liu X. The microbiota-gut-brain axis and neurodevelopmental disorders. Protein Cell. 2023;14(10):762–75.
Google Scholar
Yang J, et al. Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A systematic review. Psychiatry Res. 2020;293: 113471.
Google Scholar
Patusco R, Ziegler J. Role of Probiotics in Managing Gastrointestinal Dysfunction in Children with Autism Spectrum Disorder: An Update for Practitioners. Adv Nutr. 2018;9(5):637–50.
Google Scholar
Mitchell LK, Davies PSW. Pre- and probiotics in the management of children with autism and gut issues: a review of the current evidence. Eur J Clin Nutr. 2022;76(7):913–21.
Google Scholar
Song W, et al. Prebiotics and probiotics for autism spectrum disorder: a systematic review and meta-analysis of controlled clinical trials. J Med Microbiol. 2022;71(4):001510.
Google Scholar
Alvares MA, et al. Use of probiotics in pediatric patients with autism spectrum disorder: a systematic review. Revista da Associação Médica Brasileira. 2021;67:1503–7.
Google Scholar
Taylor MR, et al. Dietary and Micronutrient Treatments for Children with Neurodevelopment Disorders. Curr Dev Disord Rep. 2018;5(4):243–52.
Google Scholar
Elliott S, et al. Iron Supplementation in Management of Neurodevelopmental Disorders: Systematic Review, Meta-Analysis, and Qualitative Synthesis. J Neuropsychiatry Clin Neurosci. 2024;36:appineuropsych20230081.
Google Scholar
Rucklidge JJ, Johnstone J, Kaplan BJ. Nutrient supplementation approaches in the treatment of ADHD. Expert Rev Neurother. 2009;9(4):461–76.
Google Scholar
Sarris J, et al. Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): A systematic review of the evidence. Complement Ther Med. 2011;19(4):216–27.
Google Scholar
Granero R, et al. The Role of Iron and Zinc in the Treatment of ADHD among Children and Adolescents: A Systematic Review of Randomized Clinical Trials. Nutrients. 2021;13(11):4059.
Google Scholar
Siafis S, et al. Pharmacological and dietary-supplement treatments for autism spectrum disorder: a systematic review and network meta-analysis. Molecular Autism. 2022;13(1):10.
Google Scholar
Chang JP-C, et al. Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies. Neuropsychopharmacology. 2018;43(3):534–45.
Google Scholar
Li Y-J, Li Y-M, Xiang D-X. Supplement intervention associated with nutritional deficiencies in autism spectrum disorders: a systematic review. Eur J Nutr. 2018;57(7):2571–82.
Google Scholar
Sathe N, et al. Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic Review. Pediatr. 2017;139(6):e20170346.
Google Scholar
Händel MN, et al. Efficacy and Safety of Polyunsaturated Fatty Acids Supplementation in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents: A Systematic Review and Meta-Analysis of Clinical Trials. Nutrients. 2021;13(4):1226.
Google Scholar
Gogou M, Kolios G. The effect of dietary supplements on clinical aspects of autism spectrum disorder: A systematic review of the literature. Brain Develop. 2017;39(8):656–64.
Google Scholar
Huda MN, et al. Gut microbiota and host genetics modulate the effect of diverse diet patterns on metabolic health. Front Nutr. 2022;9: 896348.
Google Scholar
Weersma RK, Zhernakova A, Fu J. Interaction between drugs and the gut microbiome. Gut. 2020;69(8):1510.
Google Scholar
Nahidi M, Soleimanpour S, Emadzadeh M. Probiotics as a Promising Therapy in Improvement of Symptoms in Children With ADHD: A Systematic Review. J Atten Disord. 2024;28(8):1163–72.
Google Scholar
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